NRIX - Nurix Therapeutics Inc

Nurix Therapeutics, Inc. 该公司是一家生物制药公司,专注于发现、开发和商业化口服小分子疗法,旨在调节细胞蛋白水平,作为癌症和免疫紊乱的新治疗方法。利用他们在E3连接酶方面的广泛专业知识以及他们的专有DNA编码库,该公司已经建立了一个集成的发现平台 DELigase,以识别和开发针对E3连接酶的新药物候选。于2009年8月27日在特拉华州成立。


Nurix Therapeutics Inc is a biopharmaceutical company focused on the discovery, development and commercialization of oral, small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. The company's pipeline comprises targeted protein degraders of Brutons tyrosine kinase, or BTK, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, or CBL-B, an E3 ligase that regulates T cell activation. Its drug candidate from protein degradation portfolio, NX-2127, is an orally available BTK degrader for the treatment of relapsed or refractory B-cell malignancies. Its drug candidate from E3 ligase inhibitor portfolio, NX-1607, is an orally available CBL-B inhibitor for immuno-oncology indications.



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